Is interstitial fluid an adequate replacement to blood glucose testing?

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Is interstitial fluid an adequate replacement to blood glucose testing?

Interstitial fluid-based glucose readings are a reliable indicator of blood glucose levels4

  • The physiological lag in ISF glucose, with respect to changes in blood glucose, is about 5-10 minutes4
  • The average lag time of the FreeStyle Libre system is approximately 5 minutes, which is unlikely to impact routine day-to-day treatment decisions3, 4

 

Parkes J, Slatin S, Pardo S, et al. A new consensus error grid to evaluate the clinical significance of inaccuracies in the measurement of blood glucose. Diabetes Care. 2000;23(8):1143-1148.

4 Rebrin K, Sheppard NF Jr, Steil GM. Use of subcutaneous interstitial fluid glucose to estimate blood glucose: revisiting delay and sensor offset. J Diabetes Sci Technol. 2010;4(5):1087-1098.